Method to search for male antifertility drugs based on PHGPx activity determination

Method for screening for inhibitors of phospholipid hydroperoxide glutathione peroxidase (PHGPx) derived from human tissue or human cells comprising the steps of

• a) determining the enzymatic activity of said PHGPx in the absence and presence, respectively, of at least one potential inhibitor,
• b) selecting at least one inhibitor which specifically blocks PHGPx activity and subjecting said inhibitor(s) to a screening for pharmaceutical acceptance and
• c) selecting a pharmaceutically acceptable inhibitor which, by specifically blocking PHGPx, reversibly suppresses male fertility.