Methods and compositions for enhancing angiogenesis
OwnerAnthony Montgomery, Peter Brooks +1inventors
InventorsAnthony Montgomery, Peter Brooks, Ralph Reisfeld
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Abstract
This invention relates generally to the field of angiogenesis. In particular, the invention provides a method for enhancing angiogenesis, which method comprises administering an effective amount of an integrin binding pro-angiogenic agent or an integrin antagonist to a mammal, wherein angiogenesis is desirable, thereby enhancing angiogenesis in said mammal. The invention also provides isolated, angiogenic proteins or peptides or isolated nucleic acids encoding the angiogenic proteins or peptides. Combinations and methods for enhancing angiogenesis are further provided.
Claims37
A method for enhancing angiogenesis, which method comprises administering an effective amount of an integrin binding pro-angiogenic agent to a mammal, wherein angiogenesis is desirable, thereby enhancing angiogenesis in said mammal.
An isolated protein or peptide, which protein or peptide is selected from the group consisting of the entire extracellular domain of the NCAM L1 or a functional derivative or fragment thereof that substantially retains its binding affinity with the integrin, a NCAM L1 comprising the Ig-like domains 4-6 (Ig 4-6) or a functional derivative or fragment thereof that substantially retains its binding affinity with the integrin, a protein or a peptide that specifically binds to an antibody that is raised against a peptide having the following amino acid sequence:
- PSITWRGDGRDLQEL and a peptide having the following amino acid sequence:
- PSITWRGDGRDLQEL.
An isolated nucleic acid, which nucleic acid encodes a protein or peptide selected from the group consisting of the entire extracellular domain of the NCAM L1 or a functional derivative or fragment thereof that substantially retains its binding affinity with the integrin, a NCAM L1 comprising the Ig-like domains 4-6 (Ig 4-6) or a functional derivative or fragment thereof that substantially retains its binding affinity with the integrin, a protein or a peptide that specifically binds to an antibody that is raised against a peptide having the following amino acid sequence:
- PSITWRGDGRDLQEL and a peptide having the following amino acid sequence:
- PSITWRGDGRDLQEL.
A combination, which combination comprises:
- a) an effective amount of an integrin binding pro-angiogenic agent;
- and
- b) an effective amount of another angiogenic molecule.
A method for enhancing angiogenesis, which method comprises administering an effective amount of an integrin antagonist to a mammal, wherein angiogenesis is desirable, thereby enhancing angiogenesis in said mammal.
A combination, which combination comprises:
- a) an effective amount of an integrin antagonist;
- and
- b) an effective amount of another angiogenic molecule.
Dependencies are inferred from the claim text.