Humanized antibodies against human 4-1BB
AssigneeBristol-Myers Squibb Company
InventorsMaria Jure Kunkel, Subinay Ganguly, Ralph Abraham, Diane L. Hollenbaugh, Jill Rillema, Barbara Thorne, Walter W. Shuford, Robert S. Mittler
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Abstract
A humanized antibody that binds to human 4-1BB and that allows binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating cancer in a subject comprising administering a therapeutically effective amount of the antibody to said subject.
Claims9
A humanized antibody that binds to human 4-1BB and that allows binding of human 4-1BB to a human 4-1BB ligand.
An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
- (a) nucleotides 693 to 2072 of SEQ ID NO:3;
- and
- (b) nucleotides 633 to 1034 and 1409 to 1726 of SEQ ID NO:6.
Dependencies are inferred from the claim text.