Parenteral composition for treating bacterial illnesses
OwnerVincent Pischetti, Lawrence Loomisinventors
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Abstract
The present invention discloses a method and composition for the treatment of bacterial infections by the parenteral introduction of an effective amount of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria wherein the lytic enzyme is selected from the group consisting of shuffled lytic enzymes, chimeric lytic enzymes, holin enzymes, and combinations thereof, wherein said lytic enzyme is in an appropriate carrier for delivering the lytic enzyme into a patient. The injection can be done intramuscularly, subcutaneously, or intravenously.
Claims59
1) A method for the treatment of bacterial infections, comprising:
- administering parenterally an effective amount of a therapeutic agent, said therapeutic agent comprising:
- at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria, wherein said at least one lytic enzyme is selected from the group consisting of shuffled lytic enzymes, chimeric lytic enzymes, holin lytic enzymes, and combinations thereof and;
- a carrier for delivering said at least one lytic enzyme to the site of the infection.
31) A composition for the treatment of bacterial infections, comprising:
- a therapeutic agent comprising:
- an effective amount of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria, wherein said at least one lytic enzyme is selected from the group consisting of shuffled lytic enzymes, chimeric lytic enzymes, holin lytic enzymes, and combinations thereof, said at least one lytic enzyme having the ability to digest a cell wall of a specific said bacteria;
- and,
- a carrier for the parenteral delivery of said at least one lytic enzyme to the site of the infection.
Dependencies are inferred from the claim text.