Interferons, uses and compositions related thereto
AssigneePestka Biomedical Laboratories, Inc.
InventorSidney Pestka
Life of this patent
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Abstract
The present disclosure provides isolated Interferonα nucleic acids and polypeptides. The disclosure also provides antibodies which specifically recognize the subject Interferonα polypeptides, expression vectors containing the subject nucleic acids, and host cells expressing the subject polypeptides. In addition, methods of treatment using Interferonα are provided.
Claims60
An isolated nucleic acid comprising a polynucleotide encoding at least a portion of an Interferon polypeptide, wherein the Interferon polypeptide includes an amino acid sequence at least 80% identical to at least one of SEQ ID NO:
- 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 68, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86 or a fragment thereof.
An isolated nucleic acid comprising a polynucleotide which hybridizes under stringent conditions to at least one of SEQ ID NO:
- 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83 or 85.
An isolated nucleic acid comprising a polynucleotide encoding at least a portion of an Interferon polypeptide, wherein the Interferon polypeptide includes an amino acid sequence at least 80% identical to at least one of SEQ ID NO:
- 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26 or a fragment thereof.
An isolated nucleic acid comprising a polynucleotide which hybridizes under stringent conditions to at least one of SEQ ID NO:
- 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23 or 25.
An isolated nucleic acid comprising a polynucleotide encoding at least a portion of an Interferon polypeptide, wherein the Interferon polypeptide includes an amino acid sequence at least 80% identical to at least one of SEQ ID NO:
- 28, 30, 32, 34, 36 or a fragment thereof.
An isolated nucleic acid comprising a polynucleotide which hybridizes under stringent conditions to at least one of SEQ ID NO:
- 27, 29, 31, 33 or 35.
An isolated nucleic acid comprising a polynucleotide encoding at least a portion of an Interferon polypeptide, wherein the Interferon polypeptide includes an amino acid sequence at least 80% identical to at least one of SEQ ID NO:
- 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 68, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86 or a fragment thereof.
An isolated nucleic acid comprising a polynucleotide which hybridizes under stringent conditions to at least one of SEQ ID NO:
- 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83 or 85.
An expression vector capable of replicating in at least one of a prokaryotic cell and a eukaryotic cell, including a nucleic acid of any of the above claims.
An isolated polypeptide comprising an amino acid sequence, wherein the amino acid sequence is at least 80% identical to at least one of SEQ ID NO:
- 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 68, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84 or 86.
An isolated polypeptide comprising an amino acid sequence, wherein the amino acid sequence is at least 80% identical to at least one of SEQ ID NO:
- 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24 or 26.
An isolated polypeptide comprising an amino acid sequence, wherein the amino acid sequence is at least 80% identical to at least one of SEQ ID NO:
- 28, 30, 32, 34 or 36.
An isolated polypeptide comprising an amino acid sequence, wherein the amino acid sequence is at least 80% identical to at least one of SEQ ID NO:
- 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 68, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84 or 86.
An isolated antibody that binds specifically to an Interferon polypeptide.
A method of treating a patient comprising administering a therapeutically effective amount of an Interferon polypeptide.
A method for identifying compounds that enhance or inhibit the biological activity of an Interferon polypeptide.
Dependencies are inferred from the claim text.