Biologically active non-antigenic copolymer and conjugates thereof and methods for producing the same
OwnerMyung-Ok Parkinventor
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Abstract
The present invention relates to activated biocompatible non-antigenic copolymers formed by copolymerizing polyethyleneimine with biocompatible polymer other than polyethyleneimine, biologically active non-antigenic conjugates formed by binding said copolymers to biologically active materials such as drugs or proteins. A biologically active non-antigenic conjugate of the present invention has a characteristic feature in that its constitutive copolymer essentially consists of hydrophilic polymer, which plays a role to provide high stability and long in vivo half-life of the hydrophobic drugs or proteins, and positively charged polymer which functions to increase the cellular uptake of the drugs or proteins.
Claims12
An activated biocompatible non-antigenic copolymer of the formula I:
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- wherein PEI indicates polyethyleneimine;
- x and y are each an integer;
- P represents biocompatible non-antigenic polymer;
- and A represents reactive functional group or methoxy (CH3O—).
A process for producing an activated biocompatible non-antigenic copolymer of the formula I:
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- wherein PEI indicates polyethyleneimine;
- x and y are each an integer;
- P represents biocompatible non-antigenic polymer;
- and A represents functional group or methoxy (CH3O—), which comprises (a) activating a biocompatible polymer (P) and reacting the resulting activated biocompatible polymer with PEI to form copolymer PEI-P, (b) activating the resulting copolymer PEI-P to produce said activated biocompatible non-antigenic copolymer.
A biologically active non-antigenic conjugate of the formulae (IIa), (IIb) or (IIc):
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- wherein PEI indicates polyethyleneimine;
- x and y are each an integer;
- P represents biocompatible non-antigenic polymer;
- and R represents biologically active material.
Dependencies are inferred from the claim text.