Preventing tooth decay and infective endocarditis using natural oligopeptides
AssigneeUniversity of Southern California
InventorsSteven D. Goodman, Olga Kay
Life of this patent
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Abstract
The present invention provides compositions, medicaments, and methods for the treatment or prophylaxis of conditions associated with the binding of Streptococcus mutans to teeth. Specifically, the present invention provides a method for preventing dental caries and infective endocarditis in a subject by treating the subject's oral cavity with a composition or medicament comprising the competence stimulating peptide (CSP) of the causative bacterium, which inhibits the ability of the said bacteria to attach to the surface of teeth. Novel anti-caries compositions using the CSP are also disclosed.
Claims20
A composition comprising Competence Stimulating Peptide (CSP) and sucrose.
A method of treatment or prophylaxis of a condition associated with the attachment of S. mutans to teeth of a subject, comprising the step of administering to the subject a composition containing CSP in an amount effective to reduce the attachment of S. mutans to teeth.
A medicament for the treatment or prophylaxis of a condition associated with the attachment of S. mutans to teeth, comprising CSP in an amount effective to reduce the attachment of S. mutans to teeth.
Dependencies are inferred from the claim text.