Identifying therapeutic compounds based on their physical-chemical properties
AssigneeEdison Pharmaceuticals, Inc.
InventorsSylvain Gilat, Gary Binyamin, Guy Miller
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Abstract
The present invention is directed to rapid and efficient methods of identifying therapeutic compounds by allowing only the most favorable molecules initially selected based on their physical-chemical profile falling within a range predefined by the physical-chemical/biological relationship of a previously tested small subset of compounds of same core structure to be assayed; and to the therapeutic compositions identified by said methods.
Claims58
A method of identifying and selecting therapeutic compounds having a predetermined core structure, said method comprising:
- establishing a relationship between physical-chemical profile and biological activity;
- wherein the physical-chemical profile comprises one or more parameters selected from onset of oxidation, potential of oxidation, potential of reduction, reversibility of oxidation, reversibility of reduction, current of oxidation or current of reduction;
- and wherein the biological activity is measured in an assay effective in detecting compounds for the treatment of a targeted disorder;
- testing further potential therapeutic candidates with said core structure for their physical-chemical properties;
- and
- selecting therapeutic compounds based on their physical-chemical parameters falling within a range predefined by the physical-chemical/biological relationship of the previously tested subset of compounds.
53 The method of claim 51 wherein the compound is for the treatment of a condition characterized by oxidative stress.
Dependencies are inferred from the claim text.