Blister package for topiramate tablets
OwnerMonika Dobler, Stefan Merkle +2inventors
InventorsMonika Dobler, Stefan Merkle, Pedro Lorca, Dieter Bachmann
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Abstract
The present invention provides a blister package for topiramate tablets comprising a pan sheet having preformed cavities containing topiramate tablets dried to a free water content of between about 0.4% to about 1.4% and a cover sheet sealed to the pan sheet. The present invention further provides a process for blister packaging dried topiramate tablets into a blister package with improved shelf-life and stability performance.
Claims21
A blister package for topiramate tablets comprising a pan sheet having preformed cavities containing topiramate tablets, and a cover sheet sealed to the pan sheet;
- wherein the topiramate tablets have a free water content of between about 0.4% to about 1.4% at the time the cover sheet is sealed to the pan sheet and wherein the blister package thus formed contains no desiccant.
The blister package of claim 0 wherein the topiramate tablets are dried using hot air.
A process for making a blister package containing topiramate tablets comprising the steps of:
- (a) drying a plurality of topiramate tablets to a free water content of between about 0.4% to about 1.4%;
- (b) placing the dried topiramate tablets from step (a) into a pan sheet having a plurality of cavities;
- and
- (c) sealing a cover sheet to the pan sheet from step (b) to form the blister package, provided that the dried topiramate tablets have a free water content of less than about 1.4% at the time the cover sheet is sealed to the pan sheet and wherein the blister package contains no desiccant.
Dependencies are inferred from the claim text.