Antisense calpain nucleotides and uses thereof
OwnerDaniel Martineau, Zhiying Zhanginventors
Life of this patent
Estimating the term…
Abstract
The present invention relates to the protection of cells against cell damage and cell death which characterize stroke and myocardial infarction. The invention relates to antisense nucleotides, or nucleotides derived thereof useful for the prevention of cell death and cell damage.
Claims7
An antisense calpain nucleotide sequence capable of hybridizing with a mRNA encoding for a protease of the calpain family and thus downregulating the expression of the protease of the calpain family.
An antisense calpain nucleotide sequence capable of hybridizing with a mRNA encoding for a protease of the calpain family and thus capable of protecting cells from damage and death.
An antisense calpain nucleotide sequence capable of hybridizing with a mRNA encoding for a protease of the calpain family, capable of triggering their destruction and thus capable of protecting cells from damage and death.
An antisense calpain sequence capable of hybridizing with the calpain mRNA region corresponding to the 3′ half of Domain III of the calpain large subunit.
An antisense calpain oligonucleotide having nucleotide sequences consisting of:
- 3 1. CGTTCAGCCA CTCCATCATG CTGAGCTCCA CGCTTCCTGA CTTATGAAAT 51. CTCACAGTCC CCTCCTGCCA GCTGTTCAAA CAGTTTTCTG AACTGATCGT 101. CCACATCGTC TTCATCGATC TCAATCGTCT CCACTCTGCT CTCGACAGGG 151. TCGTCCATCT CTTGAAAGTC AGCCTGTTTC TCGGAGAAGA CGCGGACGCA 201. GAAGTCTCCG TTCTTGTCCG GTTCGAAGGT AGACGGGAcG ATCAGGTATT 251. CTCCGGGCGG CAGACAGAAG CGGCTGCACA CCTCCCTCGG GTCGATGAAA 301. GTCTCGGAGC GAGCGGCTGA GGCATGACGC AGGAAGTAGT TCTTATTCAG 351. GTGGACGTTC CTCTGATCGC GGAACTCATC AGGAACCTGG TAGATGGCGA 401. AGCCGACCGT GTGCATGTCC TCCCCCAGCT TCCGGGCGCG GCGCCGGTTC 451. TTCTGGATCA GACCGACCAC GAAGCTGCCG CCGAGCTCGC GTCGGCCGGG 501. TCATCGTCTT CCTCCTCCAG ACGGATCACA AACTGAGGGT TGGTCCAGAA 551. CGTGTCCGGG TAGTTCCTGC A;
- or an analog thereof.
Dependencies are inferred from the claim text.