Process for detecting increased risk of fetal chromosomal abnormality
AssigneeWako Pure Chemical Industries, Ltd.
InventorsRitsu Yamamoto, Shinji Satomura
Life of this patent
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Abstract
An increased risk of a fetal chromosomal abnormality, for example, fetal Down syndrome can be detected by separating or discriminating α-fetoproteins present in the body fluid of a pregnant woman, and measuring the proportion of one or more of the α-fetoproteins which have a specific sugar chain structure, relative to the total α-fetoproteins.
Claims22
A process for detecting an increased risk of a fetal chromosomal abnormality which comprises separating α-fetoproteins present in a body fluid of a pregnant woman on the basis of the difference between or among their sugar chain structures, measuring one or more of α-fetoproteins having a specific sugar chain structure, and detecting the increased risk on the basis of a result of the measurement.
A process for detecting an increased risk of a fetal chromosomal abnormality which comprises separating α-fetoproteins present in a body fluid of a pregnant woman on the basis of the difference between or among their sugar chain structures, measuring the proportion of one or more of the α-fetoproteins which have a specific sugar chain structure, relative to the total α-fetoproteins, and detecting the increased risk on the basis of a result of the measurement.
A kit for detecting an increased risk of a fetal chromosomal abnormality, which comprises (1) a lectin capable of recognizing a specific sugar chain of at least one of α-fetoproteins and (2) an anti-α-fetoprotein antibody.
A kit for detecting an increased risk of a fetal chromosomal abnormality which comprises (1) a lectin capable of recognizing a specific sugar chain of at least one of α-fetoproteins, (2) an anti-α-fetoprotein antibody capable of binding to all α-fetoproteins irrespective of whether the lectin binds to α-fetoproteins or not and (3) an anti-α-fetoprotein antibody having a low reactivity with an α-fetoprotein(s) having the lectin attached thereto but having a high reactivity with an α-fetoprotein(s) to which the lectin does not-bind.
Dependencies are inferred from the claim text.