Inhibition of restenosis using a DNA-coated stent
OwnerStephen E. Epstein, Shmuel Fuchsinventors
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Abstract
Restenosis of arteries after angioplasty is inhibited by implanting in the treated artery a stent incorporating genes that encode gene products having anti-restenotic activity. The genes may be incorporated into a coating on the stent structure or in cells that are affixed to the stent. The genes or cells containing them may be adhered to the struts of the stent or incorporated in a collagen matrix that forms a coating covering the struts and interstices of the stent
Claims39
A method for inhibiting restenosis of blood vessels after angioplasty comprising
- providing a stent comprising a lattice of interconnected struts with openings between said struts,
- adhering DNA to at least a portion of said struts, said DNA coding for at least one substance capable of inhibiting restenosis of a blood vessel, and
- positioning said stent having DNA adhering thereto adjacent to a wall of a lumen of a blood vessel in conjunction with an angioplasty procedure.
A method for inhibiting restenosis of blood vessels after angioplasty comprising
- providing a stent comprising a lattice of interconnected struts with openings between said struts,
- adhering to at least a portion of said struts transfected endothelial cells capable of secreting at least one substance capable of inhibiting restenosis of a blood vessel, and
- positioning said stent having transfected cells adhering thereto adjacent to a wall of a lumen of a blood vessel in conjunction with an angioplasty procedure.
An intravascular stent comprising a lattice of interconnected struts with openings between said struts said stent having adhered thereto DNA coding for at least one substance capable of inhibiting restenosis of a blood vessel.
An intravascular stent comprising a lattice of interconnected struts with openings between said struts said stent having adhered thereto transfected endothelial cells capable of secreting at least one substance capable of inhibiting restenosis of a blood vessel.
Dependencies are inferred from the claim text.