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US 2004/0073277 A1Published application
High fluence rate activation of photosensitizers for dermatological applications
OwnerRoy G. Geronemus, Macrene Renee Alexiades-Armenakas +1inventors
InventorsRoy G. Geronemus, Macrene Renee Alexiades-Armenakas, Kathleen McMillan
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Abstract
Treatment of neoplastic or non-neoplastic dermatological conditions is achieved by administration and photodynamic activation of photosensitizers and pro-photosensitizers by coherent and/or incoherent light. The treatment does not cause clinically signification side effects such as purpura of the treated skin.
Claims33
A method for treating a neoplastic or non-neoplastic dermatologic condition, the method comprising:
- administering a photosensitizer or a pro-photosensitizer to a section of the skin affected with a neoplastic or non-neoplastic condition;
- allowing the photosensitizer or pro-photosensitizer to accumulate in the skin tissue affected with the neoplastic or non-neoplastic condition;
- and
- irradiating the section of the skin with a beam of light having a wavelength between about 500 nm and about 650 nm, a fluence rate of between about 100 W/cm2 and about 40 MW/cm2, and a fluence of less than about 60 J/cm2, thereby causing a therapeutic injury to the section of skin affected by the neoplastic or non-neoplastic condition without causing purpura of the skin.
1 more element
A method for treating a neoplastic or non-neoplastic dermatologic condition, the method comprising:
- applying a pro-photosensitizer to a section of the skin affected with a neoplastic or non-neoplastic condition;
- allowing the pro-photosensitizer to accumulate and metabolize in the skin tissue affected with the neoplastic or non-neoplastic condition;
- and
- irradiating the section of the skin with a pulsed laser beam having a wavelength between about 500 nm and 650 nm, a fluence less than about 20 J/cm2, and a pulse duration between about 10 microseconds and 40 milliseconds, thereby causing a therapeutic injury to the section of skin affected by the neoplastic or non-neoplastic condition without causing purpura of the skin.
1 more element
Dependencies are inferred from the claim text.