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US 2004/0073040 A1Published application
Process and catalyst for the preparation of acetylpyridines
AssigneeLonza Ltd.
InventorRoderick John Chuck
Life of this patent
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Abstract
A process for the production of acetylopyridines of the formula (1): 1 by reacting a pyridinecarboxylic ester of the formula (II): 2 wherein R1 is C1-8-alkyl, with acetic acid in the gas phase in the presence of a catalyst. The active material of the catalyst is titanium dioxide and at least one alkali or alkaline earth metal oxide, and it is supported on an alumina-silica support having an apparent porosity of at least 50 percent. The process has the advantage of producing only small amounts of by-products (e.g, pyidine).
Claims13
A process for the preparation of an acetylpyridine of the formula
- 5
- by reacting a pyridinecarboxylic ester of the formula
- 6
- where R1 is C1-6-alkyl, with acetic acid in the gas phase in the presence of a catalyst whose active material comprises titanium dioxide and at least one alkali or alkaline earth metal oxide, wherein the catalyst comprises an alumna-silica support having an apparent porosity of at least 50%.
1 more element
A catalyst obtainable by
- (i) impregnating an alumina-silica support having an apparent porosity of at least 50% with a solution of titanium tetrachloride in aqueous hydrochloric acid to obtain a first catalyst precursor,
- (ii) drying,
- (iii) calcining,
- (iv) impregnating the calcined first catalyst precursor with a solution or suspension of a hydroxide and/or oxide of an alkali metal and/or alkaline earth metal to obtain a second catalyst precursor,
- (v) drying and
- (vi) calcining the dried second catalyst precursor.
3 more elements
Dependencies are inferred from the claim text.