Thrombin inhibitors

A compound of the general formula,

• 93
• wherein
• u is CH or N;
• Q is
• 1) —N(R25)CH(R30)—
• wherein
• the nitrogen atom is attached to R1, and
• R25 and R30 are independently selected from the group consisting of hydrogen, C3-6cycloalkyl, and C1-6alkyl, or
• 94
• wherein
• the nitrogen atom is attached to R1, and
• m is 0, 1, or 2;
• R1 is selected from the group consisting of
• 95
• wherein
• R4 and R5 are independently selected from the group consisting of hydrogen, halogen, C 14 alkoxy, C 1 alkyl, —OH, and cyano, and
• X is a bond, O, CH2, S or NH,
• 96
• wherein
• R6 is selected from the group consisting of
• d) hydrogen,
• e) —OH, and
• f) —NR19R20, where R19 and R20 are independently selected from the group consisting of
• 1) hydrogen, and
• 2) C 1-6 alkyl, unsubstituted or substituted with one or more of —OH, —COOH, C 3-7 cycloalkyl, or COOR17, where R17 is C 1-4 alkyl,
• 3) C 3-7 cycloalkyl,
• 4) C(O)OR18,
• 5) C(O)R18,
• 6) C(O)NHR18,
• 7) SO2R18,
• 8) C(O)NH2, and
• 9) CN,
• wherein R18 is selected from the group consisting of C1-4alkyl, aryl, and C 3-7 cycloalkyl, and
• R7 and R8 are independently selected from the group consisting of
• a) hydrogen,
• b) —CF3,
• c) unsubstituted C 1-6 alkyl,
• d) a ring slected from the group consisting of
• 97
• wherein R91 and R99 are independently selected from the group consisting of
• 1) hydrogen,
• 2) halogen,
• 3) C 1-4 alkoxy,
• 4) C 1-4 alkyl,
• 5) hydroxy,
• 6) CF3, and
• 7) cyano,
• e) C 3-6 cycloalkyl,
• f) C 1-6 alkyl substituted with one of the group consisting of
• 1) C 3-6 cycloalkyl,
• 2) —COOH,
• 3) —OH,
• 98
• wherein R9 and R10 are independently selected from the group consisting of
• aa) hydrogen,
• bb) halogen,
• cc) C 1-4 alkoxy,
• dd) C 1-4 alkyl,
• ee) hydroxy,
• ff) CF3 and
• gg) cyano, and
• 99
• wherein
• y is 0, 1 or 2, and
• R35 and R40 are independently selected from the group consisting of hydrogen and C 1-6 alkyl;
• R2 is selected from the group consisting of
• 1) hydrogen,
• 2) halogen,
• 3) C 1-4 alkyl,
• 4) C 3-7 cycloalkyl,
• 5) CF3,
• 6) OCF3,
• 7) C 1-4 alkoxy, and
• 8) cyano;
• and
• R12 is
• 1) a 5-membered heteroaryl ring having 2, 3, or 4 heteroatoms, provided that at least 2 heteroatoms are N, and at most 1 of the heteroatoms is S or O, said ring being unsubstituted or substituted, at any one ring atom, with C1-6 alkyl or halogen, or
• 2) a 6-membered heteroaryl ring with 1-2 nitrogen atoms, said ring being unsubstituted or substituted with with C1-6 alkyl or halogen,
• or a pharmaceutically acceptable salt thereof: