Human methionine synthase: cloning, and methods for evaluating risk of neural tube defects, cardiovascular disease, and cancer
OwnerRoy A. Gravel, Rima Rozen +3inventors
InventorsRoy A. Gravel, Rima Rozen, Daniel LeClerc, Philippe Goyette, Eric Campeau
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Abstract
The invention features a method for detecting an increased likelihood of hyperhomocysteinemia and, in turn, an increased or decreased likelihood of neural tube defects or cardiovascular disease. The invention also features therapeutic methods for reducing the risk of neural tube defects, colon cancers and related cancers. Also provided are the sequences of the human methionine synthase gene and protein and compounds and kits for performing the methods of the invention.
Claims10
A substantially pure human nucleic acid comprising at least 40 nucleotides that hybridizes under high stringency conditions to a sequence found within the nucleic acid of SEQ ID NO:1.
A substantially pure human nucleic acid, wherein the sequence of said nucleic acid is at least 75% identical to the corresponding region of at least 50 contiguous base pairs of the nucleic acid of SEQ ID NO:1.
A substantially pure human nucleic acid, wherein the sequence of said nucleic acid is at least 35% identical to the corresponding region of at least 50 contiguous base pairs of the nucleic acid of SEQ ID NO:1.
A kit for the analysis of a human methionine synthase nucleic acid, said kit comprising a nucleic acid probe useful for detecting in the nucleic acids of a human a mutation or polymorphism in said methionine synthase nucleic acid, wherein said mutation or polymorphism is selected from the group consisting of D919G, H920D, and ΔIle881.
Dependencies are inferred from the claim text.