Recombinant poxvirus for chimeric proteins of the human immunodeficiency virus
AssigneeCentro de Ingenieria Genetica y Biotecnologia
InventorsEnrique Iglesias Perez, Dania M Vazquez Blomquist, Carlos A Duarte Cano
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Abstract
The invention relates to HIV chimeric gene formed by the union of fragments of different genes of said virus, wherein said fragments contains epitopes for cytotoxic T cells (CTL) or HIV-1 auxiliary T cells, which are presented by a wide range of antigens of type Major Histocompatibility Complex (HLA-I). Recombinant poxviruses are obtained from said genes, which are useful for prophylactic and therapeutic vaccination against HIV/AIDS infections, are capable of generating a protective immune cell response in vaccinated laboratory animals and are recognized by the CTL lymphocytes of HIV/AIDS patients.
Claims27
A chimeric gene containing fragments from different HIV-1 genes, where those fragments encodes for cytotoxic T cells (CTL) epitopes rich regions, which are presented by a wide range of Major Histocompatiblity Complex (HLA-1) antigens, and can also contain T helper (Th) cells epitopes from HIV and at least one B cell epitope that is the target of a monoclonal antibody.
A chimeric protein which amino acid sequence corresponds essentially with the sequence of the protein CR3.
A recombinant virus for an heterologous gene, which contains fragments from different HIV-1 genes, where those fragments encodes for CTL epitopes rich regions, which are presented by a wide range of HLA-1 antigens, and can contain also HIV-1 T helper cell epitopes and at least one B cell epitope recognized by a Mab.
Dependencies are inferred from the claim text.