Antibody against norwalk virus and method of detecting virus by using the antibody
OwnerTsutomu Kageyama, Shigeyuki Kojima +3inventors
InventorsTsutomu Kageyama, Shigeyuki Kojima, Shuetsu Fukushi, Fuminori Hoshino, Kazuhiko Katayama
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Abstract
Immunogens containing antigen peptides specific for Norwalk virus which are selected from the amino acid sequences represented by SEQ ID NOs: 1 to 4, etc. and Norwalk-virus-specific antibodies against the immunogens are constructed. By detecting a virus with the use of such virus-specific antibodies, Norwalk virus can be conveniently and accurately detected.
Claims15
An immunogen containing an antigen peptide composed of 4 to 11 continuous amino acid residues that fall within the amino acid sequence of SEQ ID NO:
- 1.
An immunogen containing an antigen peptide composed of 4 to 12 continuous amino acid residues that fall within the amino acid sequence of SEQ ID NO:
- 2.
An immunogen containing an antigen peptide composed of 4 to 9 continuous amino acid residues that fall within the amino acid sequence of SEQ ID NO:
- 3.
An immunogen containing an antigen peptide composed of 4 to 11 continuous amino acid residues that fall within the amino acid sequence of SEQ ID NO:
- 4.
An antibody which takes, as an antigen, an immunogen containing an antigen peptide composed of 4 to 11 continuous amino acid residues that fall within the amino acid sequence of SEQ ID NO:
- 1 or an immunogen containing an antigen peptide composed of 4 to 12 continuous amino acid residues that fall within the amino acid sequence of SEQ ID NO:
- 2, and is capable of binding to Norwalk virus (G1) but not binding to Norwalk virus (G2).
An antibody which takes, as an antigen, an immunogen containing an antigen peptide composed of 4 to 9 continuous amino acid residues that fall within the amino acid sequence of SEQ ID NO:
- 3 or an immunogen containing an antigen peptide composed of 4 to 11 continuous amino acid residues that fall within the amino acid sequence of SEQ ID NO:
- 4, and is capable of binding to both Norwalk virus (G1) and Norwalk virus (G2).
A monoclonal antibody which takes, as an antigen, an immunogen containing an antigen peptide composed of 4 to 9 continuous amino acid residues that fall within the amino acid sequence of SEQ ID NO:
- 3 or an immunogen containing an antigen peptide composed of 4 to 11 continuous amino acid residues that fall within the amino acid sequence of SEQ ID NO:
- 4, and is capable of binding to Norwalk virus (G2) but not binding to Norwalk virus (G1).
Dependencies are inferred from the claim text.