Novel compounds for modulating cell proliferation

A compound of Formula I, and salts, solvates or hydrates thereof:

• 44
• wherein
• R1 and R2 are each independently selected from the group consisting of H, OH, C1-6alkyl, C1-6alkoxy, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), SH, S—C1-6alkyl, O—Si(C1-6alkyl)(C1-6alkyl)(C1-6alkyl), NO2, CF3, OCF3 and halo;
• R3 is selected from the group consisting of H, OH, C1-6alkyl, C1-6alkoxy, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), SH, S—C1- 6alkyl, O—Si(C1-6alkyl)(C1-6alkyl)(C1-6alkyl), NO2, halo and CH2—S—(CH2)nAr;
• R4 is selected from the group consisting of C(X)R5, SO3Ar, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), P(O)(OH)2, P(O)(OC1-6alkyl)2, and C(NH2)═C(CN)2;
• X is selected from O, S, NH and N—C1-6alkyl;
• R5 is selected from the group consisting of NH2, OH, NH(CH2)pAr, NH(CH2)pOH, (CH2)pOC1-6alkyl, C1-6alkyl, C1-6alkoxy, NHNH2, NHC(O)NH2, NHC(O)C1-6alkoxy, N-morpholino and N-pyrrolidino;
• and
• Ar is an aromatic or heteroaromatic group, unsubstituted or substituted with 1-4 substituents, independently selected from the group consisting of OH, C1-6alkyl, C1-6alkoxy, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), SH, S—C1-6alkyl, NO2, CF3, OCF3 and halo;
• n is 0 to 4;
• and
• p is 1-4.