Sterols bearing pendant allosteric effectors of hemoglobin, and uses thereof
OwnerYves Claude Nicolau, Jean-Marie Lehn +2inventors
InventorsYves Claude Nicolau, Jean-Marie Lehn, Konstantina Fylaktakidou, Stephane P. Vincent
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Abstract
The present invention comprises compounds, compositions thereof, and methods capable of delivering a broad range of anionic molecules to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering a ligand for the allosteric site of hemoglobin to the cytoplasm of the red blood cells.
Claims52
A composition, comprising an aliphatic ammonium cation, wherein the aliphatic ammonium cation is a lipophilic, water-soluble aliphatic ammonium cation;
- and a phosphorylated inositol or a phosphorylated glyceric acid covalently bound to a sterol moiety.
A compound represented by structure 1:
- 17
- wherein
- C+ represents independently for each occurrence an aliphatic ammonium cation, an alkali metal cation, or an alkaline earth cation;
- provided that at least one instance of C+ represents an aliphatic ammonium cation;
- An− represents an anionic ligand for a mammalian cellular receptor;
- R is an oxycarbonyl (—C(O)O—) linking group;
- M is a lipophilic moiety;
- and
- n is an integer in the range 1 to 11 inclusive.
Dependencies are inferred from the claim text.