Method and medicament for inhibiting the expression of a given gene
AssigneeRibopharma AG
InventorsRoland Kreutzer, Stefan Limmer
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Abstract
The present invention relates to the specific inhibition of expression of a target gene in mammals using a short double stranded RNA. The dsRNA is less than 49 nucleotides in length and has a nucleotide sequence which is complementary to at least a part of the target gene. The dsRNAs of the present invention are useful for treating diseases, for example, cancer, viral diseases or neurodegenerative diseases.
Claims1
A composition comprising a mammalian target gene and an exogenous oligoribonucleotide having a double stranded structure (dsRNA), comprising two separate RNA strands, wherein one strand of the dsRNA has a region which is complementary to an RNA transcript of at least a part of said target gene, wherein the dsRNA is 10-1000 nucleotides in length.
Dependencies are inferred from the claim text.