Back to results
US 2004/0072729 A1Published application
High oxygen affinity PEG-hemoglobin as treatment for brain stroke
AssigneeSunBio Inc.
InventorsNho Kwang, Park Minkoo, Lee Ji-Won
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeSunBio Inc.
InventorsNho Kwang, Park Minkoo, Lee Ji-Won
Estimating the term…
The invention relates to a method for treating symptoms such as stroke comprising administering PEG-hemoglobin (polyethylene glycol-conjugated hemoglobin) solution with specific ability to deliver oxygen to cells under ischemia or hypoxia. The PEG-hemoglobin of the present invention is an oxygen carrier having demonstrated therapeutic efficacy in treatment of brain strokes. The PEG-hemoglobin disclosed in this invention has a unique ability to unload most of the carried oxygen at the site of very low oxygen milieu. This characteristic is attributed to the relatively low p50 value (8-12 mmHg) of this invention. The invention is readily applicable to restore normal oxygen level for oxygen-deprived cells such as ischemic brain cells under stroke.
A method for treating symptoms by delivering oxygen to cells and tissues comprising administering therapeutically appropriate amount of polyethylene glycol-hemoglobin solution to the mammal, wherein said polyethylene glycol-hemoglobin solution has a concentration of between 7 and 13 g/dl.
Dependencies are inferred from the claim text.