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US 2004/0072306 A1Published application
Method for producing d-pantothenic acid and/or salts thereof as an additive for animal feed
AssigneeBASF SE
InventorsKai-Uwe Baldenius, Andreas Fischer, Christine Beck, Hans-Peter Harz, Markus Lohscheidt, Martin Leemann
Life of this patent
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Abstract
The invention relates to an improved method for producing D-pantothenic acid and/or salts thereof and to the use thereof as an additive for animal feed.
Claims26
A process for preparing D-pantothenic acid and/or salts thereof which comprises
- a) using at least one organism which produces D-pantothenic acid and in which the biosynthesis of pantothenic acid (pan) and/or isoleucine/valine (ilv) is deregulated and which forms at least 2 g/l of salts of D-pantothenic acid by fermentation in a culture medium, 0-20 g/l of free β-alanine and/or β-alanine salt being supplied to the culture medium,
- b) passing the D-pantothenate-containing fermentation solution through one or more ion-selective membrane(s) by applying an electric field, low-molecular-weight ions being removed from the D-pantothenate-containing solution,
- c) adding a calcium base and/or magnesium base to set the free D-pantothenic acid contained in the solution to a pH of 3-10, a solution being obtained which contains calcium and/or magnesium pantothenate and
- d) subjecting the calcium pantothenate- and/or magnesium pantothenate-containing solution to drying and/or formulation.
1 more element
A composition for the use as animal feed additive and/or animal feed supplement, wherein it can be prepared by
- a) using at least one organism which produces D-pantothenic acid and in which the biosynthesis of pantothenic acid (pan) and/or isoleucine/valine (ilv) is deregulated and which forms at least 2 g/l of salts of D-pantothenic acid by fermentation in a culture medium, 0-20 g/l, preferably 0 g/l, of free β-alanine and/or β-alanine salt being supplied to the culture medium,
- b) passing the D-pantothenate-containing fermentation solution through one or more ion-selective membrane(s) by applying an electric field, low-molecular-weight ions being removed from the D-pantothenate-containing solution,
- c) adding a calcium base and/or magnesium base to set the free D-pantothenic acid contained in the solution to a pH of 3-10, a solution being obtained which contains calcium and/or magnesium pantothenate and
- d) subjecting the calcium pantothenate- and/or magnesium pantothenate-containing solution to drying and/or formulation.
1 more element
Dependencies are inferred from the claim text.