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US 2004/0072286 A1Published application
Extracellular matrix protein
OwnerHendrik Cornelis Heus, Robert Louis Hubert Nelisssen +1inventors
InventorsHendrik Cornelis Heus, Robert Louis Hubert Nelisssen, Cornelis Maria Leonardus Meeuwisse
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Abstract
The invention describes a novel protein and variants thereof as well as the genes coding for these proteins. The protein is useful in the prevention of inflammatory diseases, more specifically in the induction of T cell tolerance to the protein in patients suffering from rheumatoid arthritis.
Claims21
A polynucleotide encoding a polypeptide comprising the amino acid sequence extending from amino acid number 1-598 of SEQ ID NO:
- 2.
A method for identifying tolerogenic peptides, said method comprising the steps of
- a) chemically synthesizing a fragment of SEQ ID NO:
- 2, SEQ ID NO:
- 19, SEQ ID NO:
- 20 or SEQ ID NO:
- 21;
- b) bringing the peptide fragment in contact with antigen presenting cells and T cells;
- and
- c) establishing the T cell activity.
5 more elements
Dependencies are inferred from the claim text.