Methods for treating neuronal disorders
OwnerRobert M. Friedlanderinventor
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Abstract
The invention features methods for the treatment of neuronal disorders using compounds that reduce or inhibit cytochrome c release. The invention also features methods for identifying compounds that reduce or inhibit cytochrome c release for the treatment of neuronal disorders.
Claims21
A method for treating amyotrophic lateral sclerosis (ALS) in a subject in need thereof, said method comprising administering to said subject a therapeutically effective amount of a compound that reduces cytochrome c release by cells of said subject.
A method for treating cerebral ischemia in a subject in need thereof, said method comprising administering to said subject a therapeutically effective amount of a compound that reduces or inhibits cytochrome c release by cells of said subject.
A method of determining whether a test substance has the potential to treat a neuronal disorder, said method comprising the steps of:
- a) providing a cell-free mitochondrial preparation;
- b) contacting said test substance with said mitochondrial preparation;
- and
- c) determining whether said test substance induces a change in a property of said cell-free mitochondrial preparation.
A method of determining whether a test substance has the potential to treat a neuronal disorder, said method comprising the steps of:
- a) providing a cell;
- b) contacting said cell with said test substance;
- and
- c) determining whether said test substance reduces or inhibits cytochrome c release by mitochondria of said cell, relative to cytochrome c release by mitochondria of a cell not contacted by said test substance.
A method of determining whether a test substance has the potential to treat a neuronal disorder, said method comprising the steps of:
- a) providing a non-human mammal;
- b) administering said test substance to said non-human mammal;
- and
- c) determining whether said test substance reduces or prevents cytochrome c release by mitochondria in cells of said non-human mammal, relative to cytochrome c release by mitochondria in cells of a non-human mammal not administered said test substance.
Dependencies are inferred from the claim text.