Transglutaminase gene products
AssigneeUniversity College Cardiff Consultants Limited
InventorsDaniel Peter Aeschlimann, Pascale Marie Grenard
Life of this patent
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Abstract
The invention provides a nucleotide sequence comprising at least a portion of the nucleotide sequence of FIG. 10A, FIG. 6B or FIG. 10A or FIG. 10B; nucleotides which hybridise to the nucleotide sequences of FIG. 6A, FIG. 6B or FIG. 10A or FIG. 10B; nucleotides which are degenerate to the nucleotide sequences of FIG. 6A, FIG. 6B or FIG. 10A or FIG. 10B; all of which nucleotides encode a polypeptide having transglutaminase activity.
Claims34
A nucleotide sequence comprising at least a portion of the nucleotide sequence of FIG. 6A or FIG. 6B;
- a nucleotide sequence which hybridise to the nucleotide sequence of FIG. 6A or FIG. 6B;
- a nucleotide sequence which is degenerate to the nucleotide sequence of FIG. 6A or FIG. 6B;
- all of which nucleotide sequences encode a polypeptide having transglutaminase activity.
A nucleotide sequence which hybridises under stringent conditions to the nucleotide sequence of FIG. 6A or FIG. 6B and which encodes a polypeptide having transglutaminase activity.
A method of expressing a polypeptide comprising inserting a nucleotide sequence according to any preceding claim into a suitable host and expressing that nucleotide sequence in order to express a polypeptide having transglutaminase activity.
A polypeptide having an amino acid sequence comprising at least a portion of the amino acid sequence of FIG. 6A or FIG. 6B and which has transglutaminase activity.
A method of gene therapy comprising correcting mutations in a non wild type nucleotide sequence corresponding to a nucleotide sequence of FIG. 6A or FIG. 6B.
A nucleotide sequence comprising at least a portion of the nucleotide sequence of FIG. 10A or FIG. 10B;
- a nucleotide sequence which hybridise to the nucleotide sequence of FIG. 10A or FIG. 10B;
- a nucleotide sequence which is degenerate to the nucleotide sequence of FIG. 10A or FIG. 10B;
- all of which nucleotide sequences encode a polypeptide having transglutaminase activity.
A nucleotide sequence which hybridises under stringent conditions to the nucleotide sequence of FIG. 10A or FIG. 10B and which encodes a polypeptide having transglutaminase activity.
A polypeptide having an amino acid sequence comprising at least a portion of the amino acid sequences of FIG. 10A or FIG. 10B and which has transglutaminase activity.
A method of gene therapy comprising correcting mutations in a non-wild type nucleotide sequence corresponding to the nucleotide sequence of FIG. 10A or FIG. 10B.
A method of diagnosis of autoimmune disease comprising taking a sample from a subject and testing that sample for the presence of a transglutaminase encoded by the nucleotide sequences of FIG. 6A, FIG. 6B, FIG. 10A or FIG. 10B, or portions thereof.
A competitive protein binding assay for the differential diagnosis of autoimmune diseases comprising the detection of antibodies against the transglutaminase encoded by the nucleotide sequences of FIG. 6A, FIG. 6B, FIG. 10A or FIG. 10B, or portions thereof.
Dependencies are inferred from the claim text.