Isolated nucleic acid molecules which encode a soluble IL-TIF receptor or binding protein which binds to IL-TIF/IL-22, and uses thereof
AssigneeWyeth
InventorsJean-Christophe Renauld, Laure Dumourjer
Life of this patent
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Abstract
The invention relates to soluble proteins which bind to the molecule known as IL-TIF/IL-22. The proteins can antagonize the effect of IL-TIF/IL-22 on target cells. The nucleic acid molecules encoding the proteins, and uses of the protein, are also described.
Claims30
An isolated nucleic acid molecule which encodes a soluble protein which binds to ILTIF/IL-22, wherein the complimentary nucleotide sequence of said isolated nucleic acid molecule, hybridizes, under stringent conditions, to SEQ ID NO:
- 5 or SEQ ID NO:
- 10.
Isolated, soluble binding protein which binds to IL-TIF/IL-22, having a molecular weight of from about 23 to about 40 kilodaltons, as determined by SDS-PAGE.
A method for determining expression of nucleic acid molecule which encodes a protein antagonist of IL-TIF/IL-22 binding protein in a sample, comprising contacting said sample with an oligonucleotide which hybridizes specifically, under stringent conditions to the nucleotide sequence of SEQ ID NO:
- 5 or SEQ ID NO:
- 10, hybridization thereto being indicative of expression of said nucleic acid molecule.
An isolated oligonucleotide consisting of from 17 to 100 contiguous nucleotides of SEQ ID NO:
- 5 or SEQ ID NO:
- 10.
Dependencies are inferred from the claim text.