Ion exchange materials for use in a 213Bi generator
AssigneesLynntech, Inc., U Chicago Argonne LLC, The Texas A&M University System
InventorPaul Sylvester
Life of this patent
Estimating the term…
Abstract
A bismuth-213 generator comprising an insoluble composition having the general formula Zr(Phosponate)x(HPO4)2−x.nH2O, wherein x is between 0 and 2; and n is the number of waters of hydration; and wherein cations of radioactive isotopes selected from radium, actinium and combinations thereof are immobilized on the composition. The value of x may be between about 0.2 and about 1. The phosphonate may be n-phosphonomethyl-miniodiacetic acid (PMIDA), wherein x may be between about 0.1 and about 1.9. The phosphonate may be one or more phosphonate having the formula: H2O3P—(CH2)a-N—((CH2)bCO2H)—((CH2)cCO2H), wherein a, b, and c are numbers from 1 to 3 that may or may not be equal. The value of x may also be between about 0.1 and 1.9.
Claims31
A radionuclide generator comprising:
- an organic zirconium phosphate or phosphonate composition prepared by reacting a source of zirconium with a mixture of phosphoric acid and a substituted phosphoric or phosphonic acid, wherein the composition has cations of one or more radioisotopes immobilized on the composition.
A bismuth-213 generator, comprising:
- an insoluble composition having the general formula:
- Zr(Phosponate)x(HPO4)2−x*nH2O
- wherein:
- x is between 0 and 2;
- and n is the number of waters of hydration;
- wherein cations of one or more radioactive isotopes are immobilized on the composition.
A bismuth-213 generator comprising an elutable container defining an eluant flow path, the container containing a matrix comprising a substantially non-elutable inorganic layered zirconium compound containing a mixture of phosphate and phosphonate ligands compound containing actinium-225.
A radionuclide generator for producing bismuth-213 comprising an insoluble inorganic layered phosphate or phosphonate matrix including a compound containing actinium-225, the matrix being permeable to fluid passage and permitting diffusion of bismuth-213 through the matrix.
A method comprising:
- immobilizing cations of radioactive isotopes selected from radium-225, actinium-225 and combinations thereof onto an insoluble zirconium phosphate/phosphonate cation exchange composition;
- and
- eluting bismuth-213 from the insoluble composition with an aqueous solution.
Dependencies are inferred from the claim text.