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US 2004/0064050 A1Published application
System and method for screening tissue
OwnerJun Liu, Mauro Ferrari +2inventors
InventorsJun Liu, Mauro Ferrari, Stanislav I. Rokhlin, Daniel D. Sedmak
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Abstract
A system and method for screening tissue is provided. The system provides a computer-based system for distinguishing between normal and potentially abnormal tissue. The system includes computer components for generating and receiving ultrasonic waves, for storing a tissue model, and for analyzing received ultrasonic waves in the context of the tissue model.
Claims36
A tissue screening system, comprising:
- an ultrasonic wave producer that produces a first ultrasonic wave that is directed at a tissue to be screened;
- an ultrasonic wave receiver that receives one or more second ultrasonic waves, where the second ultrasonic waves are produced by the first ultrasonic wave interacting with the tissue to be screened;
- and
- an analyzer operably connected to one or more of the ultrasonic wave producer and the ultrasonic wave receiver, where the analyzer differentiates tissue regions in the tissue to be screened based, at least in part, on analyzing one or more relationships between the first ultrasonic wave and the second ultrasonic waves.
1 more element
A method for screening tissue, comprising:
- directing an ultrasonic wave at a tissue to be screened;
- receiving one or more second ultrasonic waves produced by the first ultrasonic wave interacting with the tissue to be screened;
- and
- determining whether an area of the tissue to be screened should be tagged, where the determining includes analyzing one or more parameters associated with the second ultrasonic waves in the context of a tissue mechanical properties model.
1 more element
A tissue area mapping method, comprising:
- identifying one or more first data values for a set of tissue area parameters by processing a first resultant ultrasonic wave received from a tissue area, where the first resultant ultrasonic wave is the result of a first incident ultrasonic wave interacting with the tissue area;
- storing the first data values;
- at a later time, identifying one or more second data values for the set of tissue area parameters by processing a second resultant ultrasonic wave received from the tissue area, where the second resultant ultrasonic wave is the result of a second incident ultrasonic wave interacting with the tissue area;
- and
- selectively tagging a pathologically interesting tissue location in the tissue area based, at least in part, on analyzing tissue mechanical properties discernible by analyzing one or more of the first data values, the second data values, and relations between the first and second data values.
2 more elements
An automated pathology slide reader, comprising:
- a slide holder for holding a slide on which tissue is located, the tissue being located between two first layers, the slide being immersed in a fluid;
- an ultrasound wave generator for producing incident ultrasonic waves that are directed at the slide at an incident angle;
- an ultrasound wave receiver for receiving a reflected ultrasonic wave produced by the incident wave interacting with the tissue on the slide, where the reflected ultrasonic wave is reflected from the slide at a reflection angle;
- and
- a comparison computer component for comparing one or more of, the incident angle, the reflected angle, reflection spectra, the incident wave, and the reflected wave, and determining one or more tissue properties.
2 more elements
A tissue screening system, comprising:
- means for generating a first ultrasonic wave;
- means for directing the first ultrasonic wave at a tissue sample to be screened;
- means for collecting a second ultrasonic wave produced from a mechanical interaction of the first ultrasonic wave and the tissue sample to be screened;
- means for modeling one or more modeled mechanical properties of tissue into one or more modeled mechanical properties of tissue;
- means for correlating the one or more mechanical properties with one or more mechanical interactions between a tissue sample and an ultrasonic wave;
- and
- means for identifying pathologically interesting regions of the tissue sample based, at least in part, on correlating the one or more mechanical properties with one or more mechanical interactions between the tissue sample, the first ultrasonic wave, and the second ultrasonic wave in the context of the modeled mechanical properties.
4 more elements
A method for building a model that characterizes tissue response to ultrasonic waves, comprising:
- acquiring a set of known normal tissue samples;
- analyzing the set of normal tissue samples employing ultrasonic waves and a nanomechanical representation of the normal tissue samples to produce a first analysis data;
- acquiring a set of known malignant tissue samples;
- analyzing the set of known malignant tissue samples employing ultrasonic waves and a nanomechanical representation of the malignant tissue samples to produce a second analysis data;
- characterizing tissue based, at least in part, on the first analysis data, the second analysis data, and a nanomechanical representation of tissue, where the characterizing produces a characterization data;
- and
- building a model that stores one or more of the first analysis data, the second analysis data, and the characterization data.
4 more elements
A computer readable medium having stored thereon a data structure associated with a biomechanical response model, comprising:
- a first field that stores information associated with tissue reflection properties;
- a second field that stores information associated with tissue health properties;
- and
- a third field that stores correlation information associated with correlating the tissue reflection properties of the first field and the tissue health properties of the second field.
1 more element
Dependencies are inferred from the claim text.