Process for synthesis of 1-(aminomethyl)cyclohexane acetic acid hydrochloride
AssigneeErregierre S.p.A.
InventorsMassimo Ferrari, Marcello Ghezzi, Paolo Belotti
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Abstract
A process for synthesis of 1-(aminomethyl)cyclohexane acetic acid hydrochloride (Gabapentin hydrochloride) comprising: a) Reaction of a mixture of acetic anhydride/ammonium acetate with 1,1-cyclohexane-diacetic acid to yield 3,3-pentamethylene glutarimide; b) Treatment of 3,3-pentamethylene glutarimide with sodium hydroxide in an aqueous solution up to dissolution, dripping the solution thus obtained into a sodium hydroxide/sodium hypochlorite mixture, which is also aqueous, followed by acidification with hydrochloric acid to yield gabapentine hydrochloride.
Claims10
A process for synthesis of gabapentin hydrochloride comprising:
- a) Reaction of a mixture of acetic anhydride/ammonium acetate with 1,1-cyclohexane diacetic acid to yield 3,3-pentamethylene glutarimide;
- b) Treatment of 3,3-pentamethylene glutarimide with sodium hydroxide in an aqueous solution up to dissolution, dripping the solution obtained into a sodium hydroxide/sodium hypochlorite mixture, which is also aqueous, followed by acidification with hydrochloric acid to yield gabapentine hydrochloride.
Dependencies are inferred from the claim text.