Urotensin-ll receptor antagonists

A compound of Formula I:

• 9
• wherein:
• R1 is 1,1-diphenylmethyl, 1,1-diphenylethyl, xanthyl, phenyl, benzimidazolyl, thiophenyl, 3-indolyl, or 2-indolyl, all of which may be substituted or unsubstituted by one, two, or three halogen, C1-6 alkoxy, C1-6 alkyl, benzenesulfonyl, trifluoromethyl, or trifluoromethylthio groups or they may be substituted by a benzyl, which is further substituted or unsubstituted by one, two, or three halogen, C1-6 alkoxy, or C1-6 alkyl groups;
• R2 is hydrogen or C1-3alkyl;
• R3 is independently hydrogen, C1-6 alkyl, phenyl, or benzyl, wherein the phenyl or benzyl may be substituted or unsubstituted by a methylenedioxy group, or one or two halogens, C1-3alkyl;
• or C1-3alkoxy groups;
• or both R3 groups together with the carbon they are attached to is a C3-7cycloalkcyl group;
• R4 is hydrogen or C1-3alkyl;
• R5 is hydrogen, C1-3alkoxy, or CONR6R7;
• R6 is hydrogen or C1-6 alkyl;
• R7 is hydrogen or C1-6 alkyl;
• or R6 and R7 together with the nitrogen they are attached to form a 5 or 6 membered ring;
• X is —CR8R9 or C═O;
• R8 is hydrogen or C1-3alkyl;
• R9 is hydrogen or C1-3alkyl;
• or R8 and R9 together with the carbon they are attached to form a C5-6cycloalkyl group;
• or a pharmaceutically acceptable salt thereof.