Dehalogeno compounds

A compound represented by the following general formula (I), its salts, and hydrates thereof:

• 41
• [wherein R1 represents an alkyl group having 1 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a halogenoalkyl group having 1 to 6 carbon atoms, a cyclic alkyl group having 3 to 6 carbon atoms, which may have a substituent, an aryl group, which may have a substituent, a heteroaryl group, which may have a substituent, an alkoxy group having 1 to 6 carbon atoms, or an alkylamino group having 1 to 6 carbon atoms;
• R2 represents an alkylthio group having 1 to 6 carbon atoms or a hydrogen atom,
• wherein R2 and the abovementioned R1 may be integrated to form a ring structure by incorporating a part of the mother skeleton, the thus formed ring may contain a sulfur atom as a ring-constituent atom, and the ring may be substituted by an alkyl group having 1 to 6 carbon atoms, which may have a substituent;
• R3 represents a phenylalkyl group composed of an alkylene group having 1 to 6 carbon atoms and a phenyl group, an alkyl group having 1 to 6 carbon atoms, an alkoxymethyl group having 2 to 7 carbon atoms, a hydrogen atom, a phenyl group, an acetoxymethyl group, a pivaloyloxymethyl group, an ethoxycarbonyl group, a choline group, a dimethylaminoethyl group, a 5-indanyl group, a phthalidinyl group, a 5-alkyl-2-oxo-1,3-dioxole-4-ylmethyl group, or a 3-acetoxy-2-oxobutyl group;
• R4 represents an alkyl group having 1 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, an alkynyl group having 2 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a hydrogen atom, an amino group, a hydroxyl group, a thiol group, or a halogenomethyl group, and
• among the above, the amino group may have one or more substituents selected from among the group consisting of an alkyl group having 1 to 6 carbon atoms, an acyl group having 2 to 5 carbon atoms, and a formyl group;
• A represents a nitrogen atom or a partial structure represented by formula (II):
• 42
• (wherein X represents an alkyl group having 1 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, an alkynyl group having 2 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a hydrogen atom, an amino group, a halogen atom, a cyano group, a halogenomethyl group, or a halogenomethoxy group,
• among the above, the amino group may have one ore more substituents selected from the group consisting of an alkyl group having 1 to 6 carbon atoms, an acyl group having 2 to 5 carbon atoms, and a formyl group,
• wherein X1 and the aforementioned R1 may be integrated to form a ring structure by incorporating a part of the mother skeleton, the thus formed ring may contain an oxygen atom, a nitrogen atom, or a sulfur atom as a ring constituent atom, and this ring may be substituted by an alkyl group having 1 to 6 carbon atoms, which may have a substituent);
• each of R5 and R6 independently represents an alkyl group having 1 to 6 carbon atoms, a hydrogen atom, or a substituted carboxyl group derived from an amino acid, dipeptide, or tripeptide,
• wherein the alkyl group may have one ore more substituents selected from the group consisting of an alkylthio group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a hydroxyl group, and a halogen atom;
• and
• n represents an integer 1 or 2].