Urea and urethane derivatives as integrin inhibitors

Derivatives of the formula I

• 29
• in which
• 3 X is O or NR5, Y is —N(R5)R4, —C(═NR7)—NHR7 or —C(═NR9)—NHR7, B is H or 30 R is H, A, cycloalkyl, Ar, arylalkyl or Pol, R1 is OR or N(R)2, R2 and R3 are each, independently of one another, H, A, Hal, NO2, OR, N(R)2, CN, CO—R, SO3R, SO2R, NH—C(O)A or SR, R4 is H, R7, —C(═NR7)—NHR7, —C(═NR9)—NHR7, —C(═CH—NO2)—NHR7 or Het, R5 and R5′ are each, independently of one another, H or A, R6 is Hal or NO2, R7 is H, —C(O)R8, —C(O)—Ar, R8, COOR8, COO—(CH2)O—Ar, SO2—Ar, SO2R8 or SO2-Het, R8 is A or cycloalkyl, R9 is CN or NO2, A is alkyl having 1 to 8 carbon atoms, where the alkyl groups may be monosubstituted or polysubstituted by R6 and/or their alkyl carbon chain may be interrupted by —O—, Ar is phenyl, naphthyl, anthryl or biphenylyl, each of which is unsubstituted or monosubstituted, disubstituted or trisubstituted by A, OH, OA, CN, NO2 or Hal, cycloalkyl is cycloalkyl having from 3 to 15 carbon atoms, Hal is F, Cl, Br or I, Het is a saturated, partially unsaturated or fully unsaturated monocyclic or bicyclic heterocyclic radical having from 5 to 10 ring members, where 1 or 2 N and/or 1 or 2 S or O atoms may be present, and the heterocyclic radical may be monosubstituted or disubstituted by ═O, A, NO2, NHCOA or NHA, Pol is a solid phase with no terminal functional group, n and m are each, independently of one another, 1, 2, 3, 4, 5 or 6, o is 1, 2, 3 or 4, p is 1, 2, 3, 4 or 5, and their physiologically acceptable salts and solvates.