Method for producing arrays and devices relating thereto
OwnerLarry S. Millsteininventor
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Abstract
A method of making replicate arrays, comprises repeatedly sectioning a bundle of aligned array members to make wafers comprising replicate arrays, wherein: each array comprises structural members each of which has a lumen therethrough which is continuously enclosed thereby; each array member is a homogenous composition disposed within a separate lumen of a structural member which extends from a first to a second wafer surface formed by said sectioning; and each structural member and each array member are aligned in the bundle parallel to an alignment axis and occupy a defined position in the two dimensions orthogonal thereto; wherein the array members comprise analyte binding reagents that hybridize to DNA or RNA having specific nucleotide sequences.
Claims48
A method for making arrays of a plurality of array members, comprising the steps of:
- (A) providing a plurality of array members;
- (B) forming bundle members comprising the array members;
- (C) assembling the bundle members to form a bundle in which the array members are aligned;
- (D) sectioning the bundle to produce wafers that comprise an array of the array members.
A method according to any of the foregoing claims, wherein the array members are cross-sectioned by a smooth planar cut.
A method for making arrays, comprising the step of cross-sectioning a plurality of aligned array members comprising at least two array members different from one another.
A method for making replica arrays, comprising repeatedly cross-sectioning a plurality of aligned array members to produce sections with at least one surface that exposes array members in the same disposition, thereby replicating the array.
A method for making arrays for detecting a plurality of analytes, comprising the steps of:
- (A) providing a plurality of analyte binding reagents array members;
- (B) forming bundle members comprising of or comprising the array members;
- (C) assembling the bundle members to form a bundle in which the array members are aligned;
- (D) sectioning the bundle to produce wafers that comprise an array of the analyte binding reagents.
A method for making replica arrays, comprising repeatedly cross-sectioning a plurality of aligned array members to produce sections with at least one surface that exposes array members in the same disposition, thereby replicating the array.
A method for making replica arrays for detecting a plurality of analyte, comprising repeatedly cross-sectioning a plurality of aligned analyte binding reagent array members to produce sections with at least one surface that exposes array members in the same disposition, thereby replicating the array.
Dependencies are inferred from the claim text.