Biocompatible polymer with a three-dimensional structure with communicating cells, a process for its preparation, and application in medicine and in surgery
AssigneeUniversite Pierre et Marie Curie (Paris VI)
InventorsJiri Honiger, Andre Apoil
Life of this patent
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Abstract
Disclosed are porous biocompatible polymers in the form of hydrogels, methods of preparing the hydrogels, and methods of using the hydrogels, e.g., in vitro cell culture and body implants.
Claims29
A process for producing a porous three-dimensional structure with communicating cavities constituted by at least one biocompatible polymer comprising a liquid state and a gelled or solid state, the biocompatible polymer being a hydrogel, comprising the following operations:
- preparing a frit with a pre-selected geometry and porosity constituted by a hydrosoluble or hydrolyzable substance which is not soluble in the polymer solvent and which is soluble in the polymer non-solvent;
- preparing a solution comprising a polymer in the polymer solvent;
- impregnating said frit with the polymer solution;
- placing the frit impregnated with the polymer solution under physical conditions for transforming the biocompatible polymer from the liquid state into the gelled or solid state, or a hydrogel incorporating said hydrosoluble or hydrolyzable substance;
- dissolving or hydrolyzing the frit, as appropriate, by immersing the mixture into a polymer non-solvent;
- recovering the polymer with the selected geometry and porosity in the form of a hydrogel.
A process for producing a porous three-dimensional structure with communicating cavities constituted by at least one biocompatible polymer comprising a liquid state and a gelled or solid state, the biocompatible polymer being a hydrogel, comprising the following operations:
- preparing a hydrosoluble or hydrolyzable substance which is not soluble in the polymer solvent and which is soluble in the polymer non-solvent, in the form of particles with a selected size and geometry;
- preparing a solution comprising the polymer in the polymer solvent;
- forming a heterogeneous mixture containing a solution of the polymer and a hydrosoluble or hydrolyzable substance in a mould;
- placing the mould containing the heterogeneous mixture under physical conditions for transforming the biocompatible polymer from the liquid state into the gelled or solid state or hydrogel;
- unmoulding the gelled or solidified of hydrogel mixture incorporating said hydrosoluble or hydrolyzable substance;
- as appropriate, dissolving or hydrolyzing the hydrosoluble or hydrolyzable substance in a polymer non-solvent;
- recovering the polymer with the selected geometry and porosity in the gelled or solid form or in the form of a hydrogel.
A porous three-dimensional structure with communicating cells constituted by at least one biocompatible polymer and comprising multiple cavities, which communicate with each other and with the surface of said structure, said polymer comprising a liquid state and a gelled or solid state and being in the form of a hydrogel.
Dependencies are inferred from the claim text.