Tissue defect dressings comprising proteinaceous networks

A tissue defect dressing comprising a support adapted to support a proteinaceous salve, the proteinaceous salve comprising water soluble α-keratinaceous molecules networked by interkeratin associations other than glutaraldehyde, the interkeratin associations comprising covalent bonds between the water soluble α-keratinaceous molecules comprising primarily other than disulfide bonds, said interkeratin associations producing a keratinaceous network.

A tissue defect dressing comprising:

• a support adapted to support a proteinaceous salve comprising water soluble α-keratinaceous molecules networked by interkeratin associations other than glutaraldehyde, the interkeratin associations comprising covalent bonds between the water soluble α-keratinaceous molecules comprising primarily other than disulfide bonds, said interkeratin associations producing a keratinaceous network;
• wherein the covalent bonds comprise primarily interprotein crosslinks comprising first covalent bonds between first functional groups on a plurality of molecules of a crosslinking agent and first reactive pendant groups on a plurality of first water soluble keratin molecules and second covalent bonds between second functional groups on a plurality of molecules of the crosslinking agent and second reactive pendant groups on a plurality of second water soluble keratin molecules.

159 The tissue defect dressing of claim 52 wherein at least one of a moiety selected from the group consisting of the first functional groups, the first reactive pendant groups, they second functional groups, and the second reactive pendant groups is comprises a reactive vinyl group.