Methods and devices for high throughput crystallization

A method for crystallizing a molecule, comprising:

• (a) providing a first region of a first nucleation catalyst material and a second region of a second nucleation catalyst material adjacent said first region, said first region having a variation in a nucleation property of said first nucleation catalyst material;
• (b) exposing said first and second regions to a solution of a selected molecule;
• and
• (c) growing at least one crystal of said molecule in association with said first and second regions.

A method for crystallizing molecules, comprising:

• (a) providing a plurality of first layers of a first nucleation catalyst material, and a plurality of second layers of a second nucleation catalyst material interleaved between adjacent ones of said first layers, said first layers each having a gradient in a nucleation property of said first nucleation catalyst material;
• (b) exposing said plurality of first and second layers to a solution of a selected molecule;
• and
• (c) growing at least one crystal of said molecule in association with said plurality of first and second layers.

A method for fabrication and use of a crystallization apparatus, comprising:

• (a) forming a first region comprising a first nucleation catalyst material;
• (b) forming a second region comprising a second nucleation catalyst material adjacent to said first region;
• and
• (c) creating a gradient in a nucleation property of said first nucleation material in said first region.