Aerosol drug delivery system employing formulation pre-heating
OwnerPeter D. Noymer, Justin D. Muratore +2inventors
InventorsPeter D. Noymer, Justin D. Muratore, Brooks M. Boyd, David Cipolla
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Abstract
A formulation of a drug in a liquid carrier is heated in a controlled fashion and then aerosolized. The aerosolized formulation comprises particles having an aerodynamic diameter in a range of about 0.5 to about 12 micrometers. The particles are inhaled into the lungs of a human patient thereby delivering drug to the patient. By heating the formulation prior to aerosolization, the viscosity of the formulation is reduced thereby improving delivery efficiency. Repeatability of aerosol formation is improved by pre-heating the solution to the same or substantially the same temperature for successive delivery events.
Claims44
A method of drug delivery with an aerosol drug delivery system, said method comprising:
- providing a formulation at a first temperature;
- heating said formulation to a second, predetermined temperature to reach a desired formulation viscosity;
- forming an aerosol of at least a portion of said formulation after said heating.
An aerosol drug delivery system comprising:
- a drug delivery device housing,
- a formulation container adapted to be received within said drug delivery device, a reservoir in said container being in fluid communication with an aerosolization means, wherein said aerosolization means is adapted to deliver discrete doses of formulation, and
- a heater, said heater positioned to direct thermal energy at said container.
Dependencies are inferred from the claim text.