Use of ecm degrading enzymes for the improvement of cell transplantation
OwnerOron Yacoby-Zeeviinventor
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Abstract
Cell preparations which comprise cells carrying an extracellular matrix degrading enzyme and methods of using such cell preparations for improving transplantation efficiency of such cells.
Claims132
A method of improving stem cells transplantation, the method comprising contacting the stem cells, prior to said transplantation with an effective amount of an extracellular matrix degrading enzyme and transplanting said stem cells in a recipient in need thereof.
A stem cells preparation comprising stem cells carrying an exogenous extracellular matrix degrading enzyme.
A method of improving CD34+ progenitor cells transplantation, the method comprising contacting the CD34+ progenitor cells, prior to said transplantation with an effective amount of an extracellular matrix degrading enzyme and transplanting said CD34+ progenitor cells in a recipient in need thereof.
A CD34+ progenitor cells preparation comprising CD34+ progenitor cells carrying an exogenous extracellular matrix degrading enzyme.
A method of improving bone marrow stromal cells transplantation, the method comprising contacting the bone marrow stromal cells, prior to said transplantation with an effective amount of an extracellular matrix degrading enzyme and transplanting said bone marrow stromal cells in a recipient in need thereof.
A bone marrow stromal cells preparation comprising bone marrow stromal cells carrying an exogenous extracellular matrix degrading enzyme.
A method of improving dendritic cells transplantation, the method comprising contacting the dendritic cells, prior to said transplantation with an effective amount of an extracellular matrix degrading enzyme and transplanting said dendritic cells in a recipient in need thereof.
A dendritic cells preparation comprising dendritic cells carrying an exogenous extracellular matrix degrading enzyme.
A method of improving peripheral blood lymphocyte cells transplantation, the method comprising contacting the peripheral blood lymphocyte cells, prior to said transplantation with an effective amount of an extracellular matrix degrading enzyme and transplanting said peripheral blood lymphocyte cells in a recipient in need thereof.
A peripheral blood lymphocyte cells preparation comprising peripheral blood lymphocyte cells carrying an exogenous extracellular matrix degrading enzyme.
Dependencies are inferred from the claim text.