Apparatus for determining the segmental volume of a cardiac chamber or a blood vessel of a patient, comprising a processing unit having a control output for initiating the injection of a first indicator into the bloodstream of the patient, which influences the conductance of the blood, a first detector to be placed in a cardiac chamber or blood vessel for measuring a conductance signal, which depends on the electrical conductance at the location of the detector, wherein said processing unit is arranged for calculating the segmental volume of the cardiac chamber or the blood vessel from said conductance signal, characterized by a second detector to be placed in the bloodstream for measuring an indicator signal depending on a concentration of indicator in the blood, wherein said processing unit is arranged for calculating the cardiac output from the injected quantity of indicator and the indicator signal, and calculating the segmental volume and electrical parallel conductance of a cardiac chamber or a blood vessel from the calculated cardiac output, the injected quantity of conductance indicator and the conductance signal.