Process for preparing butanetriol derivative
AssigneeDaiso Co., Ltd.
InventorsMakoto Hirata, Masafumi Mikami, Yoshiro Furukawa
Life of this patent
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Abstract
A process for preparing a butanetriol derivative of the formula (1) useful as intermediates of medicines 1 wherein R1 is the same defined below, which comprises reacting a compound of the formula (3) 2 wherein R1 and R2 are the different protecting groups, and an ethylene glycol derivative in a basic condition to prepare a compound of the formula (4) or (4a) 3 wherein R1 and R2 are the same defined above, and then subjecting the compound (4) or (4a) to selective deprotection reaction.
Claims24
A process for preparing a butanetriol derivative of the formula (1)
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- which comprises subjecting a compound of the following formula (4) or (4a) to deprotection reaction
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- wherein in the above formulae, R1 and R2 are the different each other and are protecting groups for alcohol and said protecting groups such that only R2 is removed when the deprotection reaction is carried out.
A process for preparing a butanetriol derivative of the formula (1)
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- wherein R1 is the same defined above, which comprises reacting a compound of the formula (3)
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- wherein R1 and R2 are the same defined above, and a compound of the formula (2)
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- wherein X is halogen atom or sulfonyloxy group, and R2 is the same as defined above,
- in a basic condition to prepare a compound of the formula (4)
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- wherein R1 and R2 are the same defined above, and then subjecting the compound (4) to deprotection reaction.
A process for preparing a butanetriol derivative of the formula (1)
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- wherein R1 is the same defined above, which comprises reacting a compound of the formula (3)
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- wherein R1 and R2 are the same defined above, and a compound of the following formula (2a)
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- wherein X is halogen atom or sulfonyloxy group, or ethylene oxide in a basic condition to prepare a compound of the formula (4a)
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- wherein R1 and R2 are the same defined above, and then subjecting the compound (4a) to deprotection reaction.
A process for preparing a compound (1) which comprises protecting primary hydroxy group for a compound of the formula (5)
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- wherein R2 is the same as defined above, and then carrying out the process of claim (2) or claim (3).
A process for preparing a compound (1) which comprises protecting a compound of the formula (7)
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- wherein R3 and R4 are the same or different and are hydrogen, C1-C4 alkyl or phenyl, or may form a C3-C6 cycloalkyl with the adjacent carbon atom,
- with a protecting agent of alcohol to prepare a compound of the formula (6)
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- wherein R2, R3 and R4 are the same as defined above, and then treating the compound (6) with an acid to prepare a compound (5) and then carrying out the process of claim (4).
A process for preparing a compound (1) which comprises protecting primary hydroxy group for a compound of the formula (8)
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- wherein R1 is the same as defined above, to prepare a compound (3) and then carrying out the process of claim (2) or claim (3).
A process for preparing a compound (1) which comprises reducing a compound of the formula (9)
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- wherein R5 is C1-C6 alkyl, C3-C6 cycloalkyl, phenyl, C1-C6 alkyl substituted phenyl, aralkyl or 2-alkenyl, and R1 is the same as defined above,
- with an aluminum-reducing agent or a boron-reducing agent, to prepare a compound (8) and then carrying out the process of claim (6).
A process for preparing a compound (1) which comprises protecting primary hydroxy group for a compound of the formula (10)
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- wherein R1 is the same as defined above, to prepare a compound (9) and then carrying out the process of claim (7).
A compound of the following formula (3), (5) or (8) or its optically active compound
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- wherein R1 and R2 are the same as defined above.
A compound of the following formula (4) or its optically active compound
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- wherein R1 and R2 are the same as defined above.
A compound of the following formula (4a) or its optically active compound
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- wherein R1 and R2 are the same as defined above.
Dependencies are inferred from the claim text.