Exemestane as chemopreventing agent

Use of exemestane in the manufacture of a medicament for chemoprevention or controlling the growth of estrogen dependent cancer in a patient undergoing a simultanous, separate or sequential treatment, with another chemopreventive agent selected from a taxane compound, a non-steroidal anti-inflammatory compound (NSAID), a retinoid compound, a farnesyl-protein transferase inhibitor, a matrix metalloprotease inhibitor, an αvβ3 integrin inhibitor, an anthracycline compound, an antibody against HER2, and EGFR antagonist or inhibitor, a protein kinase inhibitor, linomide, angiostatin, dehydroepiandrosterone (DHEA), a telomerase inhibitor, a cyclooxygenase inhibitor, razoxyn, platelet factor 4 (endostatin), an anti-estrogen, a VEGF inhibitor and thalidomide, or a mixture thereof.

Use of exemestane in the manufacture of a medicament in the form of an exemestane/cyclodextrin complex to be administered orally for chemoprevention or controlling the growth of estrogen dependent cancer.

Use of exemestane in the manufacture of a medicament for treating estrogen dependent cancer in a patient undergoing a simultaneous, separate or sequential treatment with another therapeutic agent selected from a non-steroidal anti-inflammatory compound (NSAID), a retinoid compound, a farnesyl-protein transferase inhibitor, a matrix metalloprotease inhibitor, an αvβ3 integrin inhibitor, a protein kinase inhibitor, linomide, angiostatin, dehydroepiandrosterone (DHEA), a telomerase inhibitor, a platelet factor 4 (endostatin), arzoxifene, idoxifene, a cyclooxygenase inhibitor, SU 5416, SU 6668, razoxyn, fluvestrant, EM 800 and thalidomide, or a mixture thereof.

Product containing exemestane and another therapeutic agent selected from a non-steroidal anti-inflammatory compound (NSAID), a retinoid compound, a farnesyl-protein transferase inhibitor, a matrix metalloprotease inhibitor, an αvβ3 integrin inhibitor, a protein kinase inhibitor, linomide, angiostatin, dehydroepiandrosterone (DHEA), a telomerase inhibitor, a platelet factor 4 (endostatin), arzoxifene, idoxifene, a cyclooxygenase inhibitor, SU 5416, SU 6668, razoxyn, fluvestrant, EM 800 and thalidomide, or a mixture thereof, as a combined preparation for simultaneous, separate or sequential use in treating estrogen dependent cancer.

Product containing exemestane and another chemopreventive agent selected from a taxane compound, a non-steroidal anti-inflammatory compound (NSAID), a retinoid compound, a farnesyl-protein transferase inhibitor, a matrix metalloprotease inhibitor, an αvβ3 integrin inhibitor, an anthracycline compound, an antibody against HER2, and EGFR antagonist or inhibitor, a protein kinase inhibitor, linomide, angiostatin, a cyclooxygenase inhibitor, razoxin, dehydroepiandrosterone (DHEA), a telomerase inhibitor, platelet factor 4 (endostatin), an anti-estrogen, a VEGF inhibitor and thalidomide, or a mixture thereof, as a combined preparation for simultaneous, separate or sequential use in chemopreventing and controlling the growth of estrogen dependent cancer.

Method for chemopreventing or controlling the growth of estrogen dependent cancer in a mammal in need of such treatment, including humans, comprising administering to said mammal a therapeutically effective amount of exemestane.

Method for chemopreventing or controlling the growth of estrogen dependent cancer in a mammal in need of such treatment, including humans, comprising administering simultaneous, separately or sequentially to said mammal, exemestane, and another chemopreventive agent selected from a taxane compound, a non-steroidal anti-inflammatory compound (NSAID), a retinoid compound, a farnesyl-protein transferase inhibitor, a matrix metalloprotease inhibitor, an αvβ3 integrin inhibitor, an anthracycline compound, an antibody against HER2, and EGFR antagonist or inhibitor, a protein kinase inhibitor, linomide, angiostatin, dehydroepiandrosterone (DHEA), a telomerase inhibitor, platelet factor 4 (endostatin), an anti-estrogen, a cyclooxygenase inhibitor, razoxyn, a VEGF inhibitor and thalidomide, or a mixture thereof;

• in amounts and close in time sufficient to produce a therapeutically useful effect.

Method for treating estrogen dependent cancer in a mammal in need of such treatment, including humans, comprising administering simultaneous, separately or sequentially to said mammal, exemestane, and another therapeutic agent selected from a non-steroidal anti-inflammatory compound (NSAID), a retinoid compound, a farnesyl-protein transferase inhibitor, a matrix metalloprotease inhibitor, an αvβ3 integrin inhibitor, a protein kinase inhibitor, linomide, angiostatin, a cyclooxygenase inhibitor, SU 5416, SU 6668, razoxyn, dehydroepiandrosterone (DHEA, a telomerase inhibitor, a platelet factor 4 (endostatin), arzoxifene, idoxifene, fluvestrant, EM 800 and thalidomide, or a mixture thereof;

• in amounts and close in time sufficient to produce a therapeutically useful effect.