Process for producing pyrimidine derivative and intermediate thereof

Abstract

The present invention relates to a method for producing a pyrimidine derivative useful as a neurocyte necrosis inhibitor and an intermediate thereof. More particularly speaking, a method for producing an acid salt of 4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine comprising reacting 4-chloro-6-(4-fluorophenyl)-2-methylpyrimidine with 5-piperidino-1-pentanol, hydrating the thus obtained 4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine and then converting the resultant hydrate into an acid salt; the hydrate as described above; and a method for producing the hydrate. According to the method of the present invention, a highly pure acid salt of 4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine can be readily and efficiently produced without using a column chromatography. Thus, this method is suitable for the production thereof on an industrial scale.

Dependencies are inferred from the claim text.