Active salt forms with tyrosine kinase activity
OwnerYu Ren, Shyam B. Karki +2inventors
InventorsYu Ren, Shyam B. Karki, Matthew M. Zhao, Mark T. Bilodeau
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Abstract
The present invention relates to orally active salt forms of the mesylate salt of 4-[2-(5-cyano-thiazol-2-ylamino)-pyridin-4-ylmethyl]-piperazine-1-carboxylic acid methylamide which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, retinal ischemia, macular edema, inflammatory diseases, and the like in mammals.
Claims33
A polymorphous form of a mesylate salt of 4-[2-(5-cyano-thiazol-2-ylamino)-pyridin-4-ylmethyl]-piperazine-1-carboxylic acid methylamide.
The method in accordance with claim 14 wherein the disease is an ocular disease.
Dependencies are inferred from the claim text.