Nitroderivatives as drugs for diseases having an inflammatory basis

Use for preparing drugs for pre cancer or cancer diseases on an inflammatory basis of nitroderivatives or salts thereof having the followin general formula (I):

• A-X1-(W)p—NO2 (I)
• wherein:
• p is an integer equal to 1 or 0;
• A=R-T1, wherein
• R is the radical of a precursor drug and it has the following formulas:
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• wherein
• s is an integer and it is 1 or 0;
• RAI is H, CH3:
• R1 is OCOR3, R3 being a C1-C5 linear or branched radical, NHCOR3, wherein R3—has the above meaning, or R1 is OH, CH2CH(CH3)2, phenyl, benzoyl, 4,6-dichlorophenylamino;
• R6 is H, or one halogen atom, preferably fluorine;
• or R1 and R6, when are located in the adjacent positions 4 and 5 of the aromatic ring of formula (AI), form the radical of following formula (AIa):
• 43
• or R can be the following formula:
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• T1=(CO)t or (X)t′, wherein X=O, S, NR1c, R1c is H or a linear or branched alkyl, having from 1 to 5 carbon atoms, t and t′ are integers and equal to zero or 1, with the proviso that t=1 when t′=0;
• t=0 when t′=1;
• X1=-TB-Y-TBI—wherein
• TB and TBI are equal or different;
• TB=(CO) when t=0, TB=X when t′=0, X being as above;
• TBI=(CO)tx or (X)txx, wherein tx and txx have the value of 0 or 1;
• with the proviso that tx=1 when txx=0;
• and tx=0 when txx=1;
• X is as above;
• Y is a bivalent linking group selected from the following:
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• wherein:
• nIX is an integer in the range 0-3, preferably 1;
• nIIX is an integer in the range 1-3, preferably 1;
• RTIX, RTIX′, RTIIX, RTIIX′, equal to or different from each other are H or a C1-C4 linear or branched alkyl;
• preferably RTIX, RTIX′, RTIIX, RTIIX′ are H;
• Y3 is a saturated, unsaturated or aromatic heterocyclic ring, having 5 or 6 atoms, containing one or two nitrogen atoms,
• an alkylene group R′ wherein R′ is a C1-C20 linear or branched when possible, preferably having from (2 to 6 carbon atoms, optionally substituted with one or more of the following groups:
• —NHCOR3, wherein R3 is as above, —NH2, —OH or
• a cycloalkylene having from 5 to 7 carbon atoms, optionally substituted with side chains R′, R′ being as above, one or more carbon atoms of the cycloalkylene ring can optionally be substituted by heteroatoms;
• or
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• wherein n3 is an integer from 0 to 3 and n3′ is an integer from 1 to 3;
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• wherein n3 and n3′ have the above meaning,
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• wherein
• R4 is hydroxy, hydrogen, R5O— alkoxy wherein R5 is a C1-C10 linear or branched or cyclic alkyl group, preferably R5 is a methyl group;
• R2 is a C2-C10 linear or branched alkenylene group which can contain one or more double bonds, preferably R2 is the ethenylene group (—CH═CH—);
• or
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• wherein R1f=H, CH3 and nf is an integer from 0 to 6;
• preferably from 0 to 4;
• L=covalent bond, or L=X, X being as above, or L=CO;
• W=YTO wherein YT has the same meanings of Y and YT in the compound of formula (I) is equal to or different from Y.