Antisense modulation of inhibitor-kappa B kinase-gamma expression
OwnerBrett P. Monia, Jacqueline Wyattinventors
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of inhibitor-kappa B kinase-gamma. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding inhibitor-kappa B kinase-gamma. Methods of using these compounds for modulation of inhibitor-kappa B kinase-gamma expression and for treatment of diseases associated with expression of inhibitor-kappa B kinase-gamma are provided.
Claims20
A compound 8 to 50 nucleobases in length targeted to a nucleic acid molecule encoding inhibitor-kappa B kinasegamma, wherein said compound specifically hybridizes with said nucleic acid molecule encoding inhibitor-kappa B kinasegamma and inhibits the expression of inhibitor-kappa B kinase-gamma.
A compound 8 to 50 nucleobases in length which specifically hybridizes with at least an 8-nucleobase portion of an active site on a nucleic acid molecule encoding inhibitor-kappa B kinase-gamma.
Dependencies are inferred from the claim text.