Agent with inactivates pathogens, comprising an element that bonds with nucleic acids and the use thereof
OwnerHans-Juergen Neumann, Helmut Knollerinventors
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Abstract
The invention relates to a pathogen-inactivating agent, as well as its use, whereby the agent contains an element that binds to nucleic acids of the pathogens, and a conjungate that destroys nucleic acid. The conjungate is created from a metal chelate complex, in which the metal can change between at least two oxidation levels. In particular, the agent can be used in physiological liquids, such as blood, or blood fractions for the inactivation of viruses.
Claims29
Pathogenic inactivating agent with an element binding to nucleic acids, characterized in that the element binding to nucleic acid contains a conjungate destroying nucleic acid, as well as possibly a spacer between both parts, and that the conjungate is a metal chelate complex, in which the metal can be oxidized, or reduced at various oxidation levels.
Pathogen-inactivating agent according to one or more of the previous claims, characterized in that the metal chelate complex is iron(III) EDTA.
Pathogen-inactivating agent according to one or more of the previous claims, characterized in that a reduction agent is additionally contained.
Pathogen-inactivating agent according to one or more of the previous claims, characterized in that the ascorbic acid or its salts exists at a concentration of more than 100 μmol/l.
Pathogen-inactivating agent according to one or more of the previous claims, characterized in that riboflavin is preferred as the intercalator.
Pathogen-inactivating agent according to one or more of the previous claims, characterized in that the pathogen-inactivating agent contains riboflavin with a covalently bound iron EDTA complex, whereby the complex can be bound to riboflavin via a spacer.
Dependencies are inferred from the claim text.