Process for preventing or reducing undesirable immunological effects to infectious agents in subjects

The process of claim 11, wherein said one or more anti-apoptotic agents are selected from the group consisting of physiologic inhibitors, viral genes and pharmacological agents, or a combination of any of the foregoing.

A kit useful for producing selective immune down regulation in an adult subject to a gene delivery component, said kit comprising in packaged combination or containers a reagent or reagents capable of producing selective immune down regulation, and buffers and instructions therefor.

A process for producing selective immune down regulation in an adult subject to an artificially expressed gene within said adult subject, the process comprising introducing into said adult subject a reagent or a combination of reagents capable of producing selective immune down regulation, said reagent or combination of reagents comprising a product or product fragment expressed from said gene.

A kit useful for producing selective immune down regulation in an adult subject to an artificially expressed gene, said kit comprising in packaged combination or containers a reagent or reagents capable of producing selective immune down regulation in an adult subject, and buffers and instructions therefor.

A process for producing selective immune down regulation in an adult subject to a gene delivery system and to a product from expression of an artificially introduced gene by said delivery system in said adult subject, said process comprising introducing to said adult subject a reagent or a combination of reagents capable of producing selective immune down regulation, said reagent or reagents comprising a component or components of said delivery system and a product or product fragment expressed from said gene.

A kit useful for producing selective immune down regulation in an adult subject to gene delivery or to expression of an artificially introduced gene in said adult subject, said kit comprising in packaged combination or containers (i) a reagent or a combination of reagents capable of producing selective immune down regulation, and optionally, (ii) one or more anti-apoptotic agents, and buffers and instructions therefor.

A process for producing selective immune down regulation in a subject to an infectious agent comprising introducing to said subject a reagent or a combination of reagents capable of producing selective immune down regulation and comprising a component or components or fragments thereof of said infectious agent.

A kit useful for producing selective immune down regulation in a subject to an infectious agent comprising in packaged combination or containers (i) a reagent or a combination of reagents capable of producing selective immune down regulation, said reagent or combination of reagents comprising a component or components or fragments thereof of said infectious agent, and (ii) buffers and instructions therefor.

A process for producing immunological tolerance in a subject to a gene delivery component or to an artificially expressed gene in said subject, or to both, said process comprising subjecting said subject to more than one immune modulating treatment, at least one of which treatment is selective immune down regulation and at least one other treatment is selected from the group consisting of general immune suppression, anti-apoptosis and selective immune down regulation.

A kit useful for producing selective immune down regulation in a subject to a gene delivery component or to an artificially expressed gene, the kit comprising in packaged combination or containers reagents or a combination of reagents capable of producing selective immune down regulation, and at least one other means for generating general immune suppression, or anti-apoptotic effects in said subject, or both, and buffers and instructions therefor.

A process for producing selective immune down regulation in a subject to a noncellular immunogenic component capable of biological function or interfering with biological function in said subject, said process comprising introducing into said subject a reagent or combination of reagents capable of producing selective immune down regulation.

A kit useful for producing selective immune down regulation in a subject to a noncellular immunogenic component capable of eliciting a biological function, said kit comprising in packaged combination or containers a reagent or combination of reagents capable of producing selective immune down regulation.

A process for producing selective immune down regulation in a subject to a native antigen or group of native antigens comprising subjecting said subject to at least two separate immune modulating treatments at least one of which comprises oral tolerization.

A process for producing immune suppression in a subject comprising administering macromolecules or compounds to said subject, said macromolecules or compounds being immunogenic or being capable of providing immune suppression, wherein said subject was treated to obtain selective immune down regulation to said macromolecules or compounds, permitting thereby repeated use of said macromolecules or compounds with substantially little or no immune response.

A process for transiently producing selective immune down regulation in a subject to a specific antigen comprising transferring non-native cells from a donor to said subject, wherein said donor that has dominant selective immune down regulation.

A process for producing selective immune down regulation in a subject to an antigen or group of antigens comprising introducing into said subject non-native compounds or non-native immunological reagents capable of producing immune suppression in said subject, wherein prior to or during or prior to and during said introduction step said subject is exposed to said antigen or group of antigens, and wherein said subject has been subjected to selective immune down regulation to said non-native compounds or non-native immunological reagents.

A transplantation process comprising introducing into a recipient subject (i) a donor liver or cells from a donor liver, and (ii) cells, tissue or organs from said donor, wherein said transplanted donor liver or donor liver cells inhibit rejection of said donor cell, tissue or organ by said recipient.

A transplantation process comprising the steps of:

• establishing selective immune down regulation in a recipient subject to the antigens of a donor;
• and
• introducing into said recipient subject cells, tissue, or organs, or components thereof from said donor.

A transplantation process comprising transplanting cells, tissue or organs from a donor to a recipient subject, wherein said recipient subject has been subjected to at least two independent immune modulating treatments, at least one of which comprises selective immune down regulation.

A process of inducing tolerance in a first subject comprising transferring cells from a second subject to said first subject, wherein selected immune down regulation has been established in said second subject by the transfer of immune cells.