Antisense modulation of LAR expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsBrett P. Monia, Sanjay Bhanot, Kenneth W. Dobie, Susan M. Freier
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of LAR. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding LAR. Methods of using these compounds for modulation of LAR expression and for treatment of diseases associated with expression of LAR are provided.
Claims20
A compound 8 to 80 nucleobases in length targeted to a nucleic acid molecule encoding LAR, wherein said compound specifically hybridizes with said nucleic acid molecule encoding LAR and inhibits the expression of LAR.
A compound 8 to 80 nucleobases in length which specifically hybridizes with at least an 8-nucleobase portion of a preferred target region on a nucleic acid molecule encoding LAR.
A method of screening for an antisense compound, the method comprising the steps of:
- a. contacting a preferred target region of a nucleic acid molecule encoding LAR with one or more candidate antisense compounds, said candidate antisense compounds comprising at least an 8-nucleobase portion which is complementary to said preferred target region, and
- b. selecting for one or more candidate antisense compounds which inhibit the expression of a nucleic acid molecule encoding LAR.
Dependencies are inferred from the claim text.