Nucleic acid delivery system, methods of synthesis and use thereof
AssigneeDana-Farber Cancer Institute, Inc.
InventorsWAYNE A. MARASCO, SI-YI CHEN
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Abstract
A nucleic acid delivery system is described. The delivery system contains a fusion protein having a target moiety and a nucleic acid binding moiety, and a nucleic acid sequence bound to the nucleic acid binding moiety of the fusion protein. The target moiety can be an antibody or a ligand. The use of this nucleic acid delivery system to transienntly or stably express a desired nucleic acid sequence in a cell is disclosed. Also disclosed is the use of this delivery system to target a cell and deliver a desired product.
Claims16
A nucleic acid delivery system comprising:
- a fusion protein containing
- (1) a targeting moiety, which will specifically bind to a site on a target cell, and
- (2) a binding moiety which will bind to a nucleic acid segment, and
- the nucleic acid segment containing a nucleic acid sequence of interest.
A nucleic acid delivery system comprising a fusion protein wherein one portion of the fusion protein comprises an antibody, which will selectively bind to a desired site on a cell, and the other portion of the fusion protein comprises a protamine protein capable of binding to a nucleic acid segment;
- and the nucleic acid segment.
Dependencies are inferred from the claim text.